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. Author manuscript; available in PMC: 2009 Jan 13.

Published in final edited form as: Am J Transplant. 2008 Jun 18;8(8):1652–1661. doi: 10.1111/j.1600-6143.2008.02302.x

Early induction of IFN-γ and CXCL9 in allografts is CD8 T cell dependent. A. C57BL/6 mice received syngeneic or complete MHC mismatched A/J cardiac allografts. Groups of 4 iso- (—) and allografts ( - - ) were harvested 24, 48, and 72 hours post-transplant, RNA was isolated from total graft homogenates, and relative real-time PCR was used to measure cytokine and chemokine expression. Data are normalized relative to isograft expression levels at 24 hours post-transplant. ( = p ≤ 0.05) B. Wild-type C57BL/6, B6.CD4^−/−, B6.CD8^−/− or B6.Rag1^−/− mice received syngeneic or A/J cardiac allografts. Groups of 5 grafts were harvested 72 hours post-transplant and intragraft levels of CXCL9 were measured by ELISA. ( = p ≤ 0.0001, = p ≤ 0.002)

Inline graphic — Early induction of IFN-γ and CXCL9 in allografts is CD8 T cell dependent. A. C57BL/6 mice received syngeneic or complete MHC mismatched A/J cardiac allografts. Groups of 4 iso- (—) and allografts ( - - ) were harvested 24, 48, and 72 hours post-transplant, RNA was isolated from total graft homogenates, and relative real-time PCR was used to measure cytokine and chemokine expression. Data are normalized relative to isograft expression levels at 24 hours post-transplant. ( = p ≤ 0.05) B. Wild-type C57BL/6, B6.CD4^−/−, B6.CD8^−/− or B6.Rag1^−/− mice received syngeneic or A/J cardiac allografts. Groups of 5 grafts were harvested 72 hours post-transplant and intragraft levels of CXCL9 were measured by ELISA. ( = p ≤ 0.0001, = p ≤ 0.002)