Table 3.
Sleep Data at Baseline and 3 Months after Randomization According to CPAP-Response
| Control group (n = 108) |
CPAP-CSA-suppressed (n = 58) |
CPAP-CSA-unsuppressed (n = 39) |
Between group P-value | ||||
|---|---|---|---|---|---|---|---|
| Baseline | 3 months | Baseline | 3 months | Baseline | 3 months | ||
| Effect on CSA | |||||||
| Total AHI, no/h | 37.8 ± 15.1 | 37.6 ± 25.7 | 33.8 ± 12.7 | 6.2 ± 3.9 | 46.9 ± 14.9 | 34.6 ± 12.4 | < 0.001* |
| Effect on Arousals | |||||||
| Arousal index, no/h | 24.8 ± 19.3 | 26.3 ± 18.6 | 24.0 ± 16.6 | 18.4 ± 15.5 | 36.4 ± 30.3 | 33.1 ± 21.5 | 0.15 |
| Effect on Sleep Structure | |||||||
| Time in bed, min | 452.4 ± 51.4 | 457.5 ± 48.9 | 456.1 ± 52.2 | 450.8 ± 44.6 | 452.8 ± 51.8 | 464.3 ± 44.9 | 0.14 |
| Sleep period time, min | 421.4 ± 52.7 | 423.7 ± 55.9 | 426.6 ± 57.3 | 420.9 ± 47.1 | 432.4 ± 50.3 | 432.0 ± 47.4 | 0.47 |
| Total sleep time, min | 310.5 ± 84.3 | 308.9 ± 77.6 | 321.4 ± 77.0 | 326.1 ± 65.3 | 314.9 ± 74.7 | 309.9 ± 83.0 | 0.88 |
| Sleep efficiency, % | 68.4 ± 16.5 | 67.8 ± 16.6 | 70.6 ± 16.2 | 72.4 ± 13.3 | 70.1 ± 16.9 | 67.3 ± 18.3 | 0.40 |
| Sleep onset latency, min | 30.8 ± 30.8 | 33.7 ± 36.5 | 28.9 ± 31.0 | 29.7 ± 29.6 | 19.9 ± 21.1 | 32.0 ± 29.4 | 0.08 |
| Wake after sleep onset, min | 111.0 ± 65.4 | 114.8 ± 70.0 | 105.3 ± 62.8 | 94.8 ± 51.5 | 117.4 ± 79.8 | 122.1 ± 80.1 | 0.36 |
| Stage 1 percentage, % | 18.2 ± 12.8 | 18.9 ± 12.9 | 18.4 ± 12.0 | 15.2 ± 14.2 | 20.3 ± 15.5 | 18.8 ± 16.9 | 0.27 |
| Stage 2 percentage, % | 58.8 ± 13.5 | 58.0 ± 14.4 | 55.8 ± 14.6 | 57.3 ± 14.8 | 57.8 ± 16.7 | 61.9 ± 16.1 | 0.20 |
| SWS percentage, % | 9.6 ± 11.0 | 10.3 ± 10.8 | 11.4 ± 10.7 | 12.6 ± 12.2 | 9.8 ± 9.3 | 8.4 ± 10.4 | 0.37 |
| REM sleep percentage, % | 13.1 ± 6.8 | 12.7 ± 7.9 | 14.4 ± 6.6 | 14.8 ± 6.3 | 12.3 ± 7.4 | 10.9 ± 7.3 | 0.45 |
| PLMI, no/h | 25.8 ± 38.9 | 24.1 ± 33.2 | 22.2 ± 32.8 | 23.3 ± 28.5 | 29.8 ± 49.8 | 32.3 ± 50.4 | 0.37 |
Values are expressed as means ± SD.
Abbreviations: AHI = apnea-hypopnea index, CSA = central sleep apnea, PLMI = periodic leg movement index, SWS = slow wave sleep.
*
Compared the changes over time between; Control vs. CPAP responder P < 0.001, Control vs. CPAP non responder P = 0.01, CPAP responder vs. CPAP non responder P = 0.002.