Table 2.
Prevalence of atopy, food allergy, CRS/ROM and primary immunodeficiency in study subjects
| Group | AR+AC | Asthma | AD | FA | CRS & ROM | PID2 | ||
| Atopy+ | Atopy - | IgE | non-IgE | |||||
| ASD1 | ||||||||
| Test3 | 7/26 (26.9%) |
2/26 (7.7%) |
2/26 (7.7%) |
1/26 (3.8%) |
2/26 (7.7%) |
23/26 (88.5%) |
6/265 (23.1%) |
5/26 (19.2%) |
| Control | 23/107 (21.5%) |
4/107 (2.4%) |
11/107 (10.3%) |
6/107 (5.6%) |
6/107 (5.6%)4 |
82/107 (76.6%) |
5/107 (4.7%) |
1/107 (0.9%) |
| CRS & ROM | 9/38 (23.7%) |
9/386 (23.7%) |
20/386 (52.6%) |
0 | 0 | 7/38 (18.4%) |
38/38 (100%) |
13/38 (34.2%) |
| FA | 5/24 (20.8%) |
2/24 (8.3%) |
2/24 (8.3%) |
2/24 (8.3%) |
3/24 (12.5%) |
22/24 (91.7%) |
1/24 (4.3%) |
1/242 (4.3%) |
| Control7 | 8/43 (18.6%) |
6/43 (14.0%) |
2/43 (4.7%) |
2/43 (4.7%) |
0 | 0 | 0 | 0 |
1 Abbreviations: AC allergic conjunctivitis, AD atopic dermatitis, AR allergic rhinitis, ASD autism spectrum disorders, CRS chronic rhinosinusitis, FA food allergy, PID primary immunodeficiency, ROM recurrent otitis media.
2 PID; ASD test/control groups: all diagnosed as specific Ab deficiency against polysaccharide Ags (SPAD), CRS/ROM group: 9 SPAD, 2 XLA, 1 dysmotile cilia syndrome, FA group: 1 patient was diagnosed as IgA deficiency. All the ASD test group children diagnosed with SPAD suffered from CRS/ROM.
3 Seizure disorders were reported in 4/26 (15.4%) ASD-Test and 2/107 (1.9%) ASD-control groups, respectively.
4 IgE mediated food allergy in ASD control group; all allergy to peanuts/tree nuts.
5 Frequency of CRS/ROM and PID were higher in the ASD test group (p = 0.0334 and p = 5.762e-07, respectively, by χ2 test).
6 Frequency of atopic asthma and non-atopic asthma is higher in CRS/ROM children than other study groups (p = 0.00722 and p = 8.885e-10, respectively, by χ2 test).
7 Control children diagnosed with asthma had either mild intermittent or mild to moderate persistent asthma and seldom required oral steroid burst.