Table 1.
Average absolute value of severity associations for the SNPs within eight candidate genes.
| Gene Name | Gene Location | Average Correlation (SD) | Count of SNPs in candidate gene | Most Correlated SNP | ||
| Name | Correlation | p-value | ||||
| POMC | 2p24 | 0.14 (NA) | 1 | rs12473543 | 0.135 | 0.216 |
| NR3C1 | 5q34 | 0.07 (0.06) | 7 | rs258750 | 0.198 | 0.069 |
| CRHR2 | 7p15 | 0.15 (0.08) | 3 | hCV15960586 | 0.225 | 0.036 |
| TH | 11p15 | 0.07 (0.01) | 2 | rs4074905 | 0.080 | 0.466 |
| TPH2 | 12q21 | 0.23 (0.04) | 7 | rs10784941 | 0.275 | 0.010 |
| SLC6A4 | 17q11.1 | 0.18 (0.17) | 3 | rs4325622 | 0.347 | 0.001 |
| CRHR1 | 17q21 | 0.03 (0.02) | 6 | rs242940 | 0.069 | 0.531 |
| COMT | 22q11.1 | 0.04 (0.02) | 7 | hCV11804654 | 0.077 | 0.479 |
TPH2 with seven SNPs had the highest average association with CFS severity.