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. 2008 Nov 10;94(1):87–93. doi: 10.3324/haematol.13483

Figure 2.

Figure 2.

XIAP knockdown increased drug sensitivity. XIAP knockdown was performed by RNA interference in both HMCLs U266 transduced by siRNA (A) and NCI-H929 transduced by shRNA (B) and evaluated by immunoblot analysis at day 1 (D1) and D3 in U266 (siXIAP) and at D7 in NCI-H929 (shXIAP) compared to control transduced cells (siCt or shCt). Myeloma cell growth was quantified by MTT test after treatment with dexamethasone (Dex) 10−6M, melphalan (Mel) 1 μM, TRAIL 10 ng/mL or AS602868 10 μM (columns, mean; bars, SD; n=3 and n=6 respectively for siRNA and shRNA experiments) and related to cell growth in corresponding untreated cells. Results were then expressed in % of cell growth inhibition compared to untreated cells. The two-way ANOVA test was used for statistical analysis (*p<0.05; **p<0.01; ***p<0.001).