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XIAP knockdown decreased NCI-H929 tumorigenicity. NCI-H929 transduced with shRNA control (shCt) or XIAP shRNA (shXIAP) were inoculated subcutaneously in NOD/SCID mice. (A) Tumor formation and measurement were assessed for 20 days (columns, mean; bars, SD; n=18). The two-way ANOVA test was used for statistical analysis (*** = p<0.001). (B) XIAP expression in tumors at the beginning (D0) and the end point (D20) of the experiment using immunoblot analysis.
