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Schematic representation of JAK2 (V617F) allele burden (middle panel) and its relationship with clinical phenotype (bottom panel), and disease complications (top panel). At low levels of mutant allele the clinical phenotype is dominated by thrombocytosis, at intermediate levels by erythrocytosis, and at higher levels by leukocytosis. Among complications, current evidence indicates a relationship between allele burden and evolution into myelofibrosis.
