FIG. 2.

Computational prediction of a plausible binding pocket on the surface of the NV capsid protein. The predicted pocket is located on top of the P2 domain and is composed of a conserved RGD-like motif (R₂₉₁) and three strain-specific hot spots, N₃₀₀, F₃₃₅, and N₃₆₈, that are located in close spatial proximity (see the text for details). Ball-and-stick models of the side chains indicate the critical residues surrounding the putative binding pocket. The oval represents the P1 domain of the capsid protein. The S domain is not shown. The Rasmol visualization program was used to prepare the figure.