TABLE 1.
Biological activity of Rex-2 proteins
| Rex-2 proteins | Positions (aa)a | Mutationsb | % Biological activity relative to wtRexc |
|---|---|---|---|
| wtRex-2 | 100 | ||
| Rex-2 M1 | 4, 9 | T, T → A, A | 54 |
| Rex-2 M5 | 65, 71 | S, S → A, A | 20 |
| Rex-2 M10 | 92, 95 | S, S → A, A | 2 |
| Rex-2 M14 | 125, 131, 132 | S, S, T → A, A, A | 30 |
| Rex-2 M16 | 144, 147, 148 | S, S, S → A, A, A | 35 |
| Rex-2 M17 | 151, 153 | S, S → A, A | 25 |
| Rex-2 DD | 151, 153 | S, S → D, D | 200 |
| Rex-2 M18 | 158 | S → A | 45 |
| Rex-2 M19 | 162, 163, 164 | T, S, T → A, A, A | 30 |
a
Positions mutated within the 170-aa HTLV-2 Rex.
b
S, serine; T, threonine; A, alanine; D, aspartic acid.
c
Biological activity relative to wtRex-2 (set at 100%) and determined to be statistically significant by Student's t test. Data were taken from Narayan et al. (45).