FIG. 3.

Amino acid sequence alignment of ORF73 positional homologs among members of the gammaherpesviruses. Amino acid sequences of ORF73 polypeptides of KSHV, rhesus rhadinovirus (RRV), HVS A11, AHV, and murine herpesvirus 68 (MHV-68) were aligned with that of HVS C488. The central repeat region (aa 332 to 921) of KSHV LANA was deleted from the alignment for simplification (↔). The carboxy-terminal domains in the polypeptides of all of the members have conserved amino acid residues, in contrast to the amino termini. Boxes indicate that residues are either identical or positive for any motif. Black shading shows that the given residue is conserved in all viral molecules investigated.