TABLE 2.
Mean log10 titers of virus in the genital tract wash fluid collected each day for 9 days following challenge with 107 PFU of the McKrae strain of HSV/mouse
| Groupa | Mean log10 titer on day:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| 1 | 3.30 ± 0.19 | 3.40 ± 0.21 | 2.78 ± 0.11 | 2.18 ± 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 2 | 3.08 ± 0.09 | 3.86 ± 0.22 | 2.90 ± 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 3 | 3.26 ± 0.12 | 4.15 ± 0.11 | 4.18 ± 0.98 | 3.70 ± 0.23 | 3.24 ± 0.29 | 2.30 ± 0.03 | 1.70 ± 0.02 | 0.00 | 0.00 |
| 4 | 4.48 ± 0.32 | 5.18 ± 1.21 | 5.00 ± 0.99 | 4.85 ± 1.07 | 4.34 ± 0.92 | —b | — | — | — |
| 5 | 2.48 ± 0.41 | 3.00 ± 1.02 | 2.11 ± 0.7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 6 | 4.61 ± 0.31 | 5.04 ± 0.20 | 4.95 ± 1.1 | 4.63 ± 1.2 | 4.54 ± 0.68 | — | — | — | — |
a
1, rVVgB-pCCL19 plus pgB-pCCL19 at boost; 2, rVVgB-pCCL21 plus pgB-pCCL21; 3, rVVgB plus pgB; 4, vector encoding β-Gal; 5, UV-inactivated HSV-1; 6, naive PBS.
b
—, death.