FIG. 1.

Generation of a CDV strain virulent for ferrets and sequence comparison with its precursor. (A) Selection of a virulent CDV strain. Onset of rash is indicated by dots, and time of death is indicated by triangles. Each pair of symbols represents one animal. (B) Nucleotide (NT) and amino acid (AA) differences between CDV5804 (5804) and CDV5804P (5804P). The amino acid exchanges are indicated with the one-letter code. The numbers refer to the residue position in the corresponding protein. The 50% label indicates that half of the clones had the A202S mutation while the other half carried the K208R mutation.