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TABLE 3.

Disease-specific transcripts differentially expressed at 17 dpi

Functiona and GenBankb Gene name Change (n-fold) for:
Cas:F43c Cas:Md F43:M Pe
Acute phase
    X58861 Complement component 1, q a 1.6 2.1 1.3 4.5E-06
    M22531 Complement component 1, q b 1.8 2.7 1.5 6.8E-06
    X66295 Complement component 1, q c 1.7 2.1 1.0 2.6E-05
    X81627 Lipocalin 2 8.6 19.6 2.3 5.5E-09
    AF045887 Angiotensinogen 1.7 1.7 1.0 2.6E-09
Apoptosis
    D83698 BH3 interacting (with BCL2 family) domain (DP5) 2.2 2.9 1.3 5.1E-04
    AV138783 Gadd 45 1.4 1.3 0.9 8.8E-05
    U88909 Baculoviral IAP repeat-containing 3 (IAP2) −2.3 −1.6 1.4 1.8E-07
Calcium binding
    X66449 Calcium binding protein A6 (calcyclin) 1.6 1.8 1.1 8.7E-04
    X59382 Parvalbumin 1.7 1.4 0.8 6.5E-03
    AB006758 Protocadherin 7 2.1 2.9 1.4 5.7E-05
    D13003 Reticulocalbin −1.6 −1.7 1.0 1.5E-04
    X14432 Thrombomodulin −1.9 −2.1 0.9 1.8E-04
Cell adhesion
    M70642 Connective tissue growth factor 2.9 2.4 0.9 1.1E-04
    AA592182 Nephronectin 1.5 1.6 1.1 7.3E-03
    U47323 Stromal interaction molecule 1 1.5 1.4 0.9 7.4E-06
    U83903 Tumor necrosis factor-induced protein 6 2.6 1.6 −1.7 8.9E-04
    U12884 Vascular cell adhesion molecule 1 2.3 3.0 1.3 3.9E-06
    X52046 Procollagen, type III, alpha 1 −2.1 −2.0 1.0 8.0E-05
    M77123 Vitronectin −1.4 −1.5 1.0 1.3E-04
    D50086 Neuropilin −1.6 −1.5 1.1 1.8E-03
    U03419 Procollagen, type I, alpha 1 −1.4 −1.4 1.0 1.3E-02
    L02918 Procollagen, type V, alpha 2 −1.5 −1.5 1.0 7.3E-03
    U16162 Procollagen-proline 2-oxoglutarate 4-dioxygenase −1.8 −2.0 0.9 3.2E-07
    M31811 Myelin-associated glycoprotein −1.6 −1.6 1.0 7.6E-04
    AI132491 Bystin-like −1.6 −1.5 1.1 3.4E-04
    A1853217 VE-cadherin gene Cdh5 −1.5 −1.5 1.0 1.2E-04
    L04678 Integrin beta 4 −1.5 −2.0 0.7 2.1E-05
Cell cycle
    U83902 Mad211 1.4 1.2 0.8 5.5E-03
    AW048937 Cyclin-dependent kinase inhibitor 1A (p21) 5.4 4.7 0.9 6.9E-11
    *AI849615f Growth arrest specific 5 (Gas5) 1.5 1.5 1.0 1.7E-04
    AW121294 Wnt1 responsive Cdc42 homolog 1.4 1.2 0.9 2.8E-03
    Z67745 Protein phosphatase 2a, catalytic subunit 1.5 1.6 1.1 6.7E-04
    AW049584 Protein phosphatase 1, regulatory (inhibitor) 2 1.9 2.5 1.3 1.6E-04
    D83745 B-cell translocation gene 3 1.4 1.8 1.3 7.1E-04
    AI843106 p53-regulated PA26 nuclear protein 1.6 1.3 0.8 4.2E-04
    *AI849928 Cyclin D1 −1.5 −1.4 1.1 2.0E-06
    M34094 Midkine −1.4 −1.4 1.1 2.5E-05
Cell growth
    AI842277 Insulin-like growth factor binding protein 3 2.2 2.4 1.1 7.3E-04
Endocytosis
    D86066 Rabaptin 5 −1.5 −1.5 1.0 2.4E-04
    AI747654 Caveolin, caveolar protein, 22 kDa −1.7 −1.6 1.1 1.4E-05
Cytoskeleton
    L29468 Cofilin 2, muscle 1.5 1.4 0.9 4.1E-03
    X57377 Myosin Va 1.9 1.9 1.0 1.1E-04
    AV170878 Rhotekin 1.6 1.4 0.9 9.6E-06
    J04953 Gelsolin −2.2 −2.0 1.1 3.3E-09
    AA657164 Rab6, kinesin-like −1.7 −1.7 1.0 2.0E-03
Creatine biosynthesis
    AI844626 Glycine amidinotransferase −1.6 −1.6 1.0 5.6E-08
    AF010499 Guanidinoacetate methyltransferase −1.5 −1.4 1.1 2.9E-04
Glycolysis/glucose metabolism
    Z11911 Glucose-6-phosphate dehydrogenase X-linked 1.6 1.3 0.8 6.5E-03
    J03928 Phosphofructokinase, liver, B-type −1.4 −1.5 0.9 3.9E-06
    X13586 2,3-Bisphosphoglycerate mutase −1.4 −1.3 1.1 6.9E-05
GTP binding
    AF009246 RAS, dexamethasone-induced 1 1.5 1.9 1.3 1.6E-03
    AW061337 Adenylate kinase 4 −1.4 −1.7 0.9 9.1E-08
ER
    AA615951 Dolichyl-phosphate beta-glucosyltransferase 1.5 1.5 1.0 6.8E-04
    AI642389 Similar to KDEL. ER protein retention receptor 3 1.6 1.9 1.2 6.6E-06
    AI851230 Homolog to ER lumen protein retaining receptor 1 −1.5 −1.2 1.2 7.4E-04/PICK>
Heat shock response/protein folding
    D85904 Heat shock protein, 110 kDa 1.4 1.6 1.1 6.9E-05
    U16959 FK506 binding protein 5 (51 kDa) 1.6 1.6 1.0 1.0E-04
    AI852161 Tubulin-specific chaperone 1.6 1.2 0.8 1.7E-04
    *X60676 Heat shock protein 47, member 1 (Hsp47) −2.6 −2.6 1.0 1.8E-06
    L40406 Heat shock protein, 105 kDa −1.6 −1.9 0.8 1.5E-05
    *AA615831 Rat ischemia responsive 94-kDa protein −1.6 −1.6 1.0 4.0E-06
    AW122022 Peptidylprolyl isomerase D (cyclophilin D) −1.5 −1.7 0.9 1.3E-06
Immune response
    AV370035 Chemokine (C-C) receptor 5 −2.8 −1.7 1.6 4.5E-04
    AV139913 Stromal cell-derived factor 1 −3.1 −2.9 1.1 4.8E-05
    AF081789 Lymphocyte antigen 68 −1.4 −1.3 1.0 1.1E-06
Lipid/cholesterol metabolism
    Z19521 Low-density lipoprotein receptor −1.4 −1.5 0.9 2.4E-05
    AB016248 Sterol-C5-desaturase homolog (Saccharomyces cerevisiae) −1.8 −1.7 1.1 2.8E-03
    AW106745 NAD(P)-dependent steroid dehydrogenase-like −1.7 −1.7 1.0 6.2E-09
    AW122653 Mevalonate kinase −1.4 −1.4 1.0 7.8E-03
    D29016 Farnesyl diphosphate farnesyl transferase 1 −1.5 −1.5 1.0 1.5E-06
    AW122260 Cytochrome P450, 51 −1.7 −1.9 0.9 7.8E-05
    Al848668 Sterol-C4-methyl oxidase-like −1.9 −2.1 0.9 1.0E-05
    Al846851 Farnesyl pyrophosphate synthase −1.8 −1.7 1.1 1.1E-05
    AF057368 7′-Dehydrocholesterol reductase −1.8 −1.7 1.0 1.9E-04
    D42048 Squalene epoxidase −1.7 −1.7 1.0 7.0E-07
    AW122523 Long-chain fatty-acyl elongase −2.1 −2.0 1.1 2.5E-07
    AW060927 2,3-Oxidosqualene: lanosterol cyclase −2.3 −2.2 1.0 1.1E-06
    U48896 UDP-glucoronosyltransferase 8 −2.1 −2.2 1.0 1.1E-06
    U28960 Phospholipid transfer protein −1.8 −1.8 1.0 1.0E-06
    X95279 Thyroid hormone responsive SPOT14 homolog −1.5 −1.7 0.9 2.4E-05
    M72394 Phospholipase A2, group IV −3.0 −2.9 1.0 1.5E-07
    AW212131 Choline phosphotransferase 1 1.5 1.8 1.2 7.2E-03
    U44389 Hydroxyprostaglandin dehydrogenase 15 (NAD) 1.9 2.4 1.3 1.5E-03
Lysosome
    M32017 Lysomal membrane glycoprotein 2 1.4 1.4 1.0 6.8E-06
    AV356071 Lysosome-associated protein transmembrane 5 1.4 1.6 1.1 1.7E-03
    U87240 Mannosidase 2, alpha B1 1.5 1.5 1.0 2.2E-05
Nucleosome assembly
    X13605 H3 histone, family 3B 1.4 1.4 1.0 1.9E-02
    X05862 H2B and H2A histone genes −1.5 −1.4 1.1 2.5E-06
    X61449 Nucleosome assembly protein 1-like 1 −1.5 −1.6 1.0 1.2E-06
Neurogenesis/survival
    U81317 Myelin-associated oligodendrocytic basic protein −2.7 −2.3 1.2 3.0E-04
    U04827 Fatty acid binding protein 7, brain −1.7 −1.2 1.4 2.5E-05
    AB017270 Tmeff2 −2.1 −2.2 1.0 1.1E-07
Polyamine biosynthesis
    L10244 Spermidine/spermine N1-acetyl transferase 2.2 2.1 1.0 3.8E-07
Proteinase inhibitor
    X93037 Extracellular proteinase inhibitor 5.0 6.7 1.4 3.9E-11
    X70393 Inter-alpha trypsin inhibitor, heavy chain 3 1.5 1.4 0.9 1.4E-04
    M64086 Serine protease inhibitor 2-2 1.7 1.7 1.0 1.1E-07
    U26437 Tissue inhibitor of metalloproteinases-3 1.5 1.3 0.9 1.2E-04
Protein biosynthesis
    U10118 Endothelial monocyte-activating polypeptide 2 1.4 1.3 0.9 1.0E-03
    AW125491 Eukaryotic translation initiation factor 2, subunit 2 1.7 1.7 1.0 2.9E-03
    AI132207 Eukaryotic translation initiation factor 1A 1.6 1.7 1.0 2.3E-03
    AI839632 Eukaryotic translation elongation factor 1 delta 1.4 1.4 0.9 2.4E-03
    *Z50159 Suil 1.5 1.3 0.9 7.7E-05
    AI835709 Ribosomal protein S25 2.0 1.5 0.8 9.1E-03
    AW048899 Ribosomal protein S19 1.4 1.4 1.0 3.1E-03
    AW125120 Mitochondrial ribosomal protein S25 −1.5 −1.3 1.1 2.3E-03
    C77227 Mitochondrial ribosomal protein S25 −1.4 −1.4 1.0 7.8E-04
Protein kinase/phosphatase
    AW046181 Serum/glucocorticoid-regulated kinase 3.8 2.9 0.8 2.1E-08
    AF039574 Serine/threonine kinase 2 1.5 1.6 1.0 4.2E-05
    D45859 Protein phosphatase 1B 3.0 3.0 1.0 1.3E-04
    AI849109 Dual specificity protein phosphatase 9 −1.5 −1.7 0.9 5.6E-05
    AF062076 Serine/threonine kinase 16 −1.5 −1.6 0.9 9.4E-06
    M95408 PTK2 protein tyrosine kinase 2 −1.6 −1.6 1.0 1.6E-05
    AV235418 Tyrosine kinase receptor 1 −1.7 −1.5 1.1 3.3E-05
    X71426 Endothelium-specific receptor tyrosine kinase −1.5 −1.6 1.0 4.5E-03
    AF077659 Homeodomain interacting protein kinase 2 −1.6 −1.4 1.1 2.6E-04
Protein degradation/proteolysis
    AI242663 Cathepsin Z 2.6 2.5 1.0 2.2E-06
    AI851255 Cathepsin B 1.7 1.7 1.0 2.4E-05
    AI848382 Ubiquitin-specific protease 1 1.4 1.3 1.0 5.0E-03
    AI846522 Ubiquitin-specific protease 2 1.7 1.5 0.9 1.1E-06
    AW228316 Hypothetical serine protease 1.5 1.4 0.9 6.1E-03
    AI746365 Beta-transducin repeat containing protein −1.6 −1.5 1.0 4.4E-04
    AA726223 a disintegrin and metalloproteinase domain 19 −1.7 −1.7 1.0 1.0E-05
RNA binding/processing
    AB016424 RNA binding motif protein 3 1.9 2.3 1.2 5.3E-06
    AI226368 Heterogenous nuclear ribonucleoprotein D-like 1.8 1.8 1.0 1.2E-04
    U11274 Heterogenous nuclear ribonucleoprotein D 1.6 2.0 1.3 4.1E-04
    AI183202 Heterogenous nuclear ribonucleoprotein A1 2.2 2.0 0.9 1.4E-03
    AI840643 Heterogenous nuclear ribonucleoprotein K 1.4 1.3 0.9 2.8E-03
    *AA684508 RNA, U22 small nucleolar (Rnu22) 1.5 1.5 1.0 3.0E-06
    AW227345 U2 small nuclear ribonucleoprotein polypeptide A 1.7 1.7 1.0 1.2E-02
    AF073993 Heterogenous nuclear ribonucleoprotein A2/B1 −1.5 −1.5 1.0 9.1E-06
    AI846595 Homolog to splicing factor, arginine/serine-rich 6 −1.9 −1.5 1.3 7.8E-05
    U65735 Elavll −1.4 −1.3 1.1 2.9E-05
Scrapie
    AJ223206 Scrapie-responsive gene 1 1.9 2.0 1.1 1.5E-09
Cell signaling
    AJ001418 Pyruvate dehydrogenase kinase 4 1.5 1.5 1.0 9.0E-03
    AB015978 Oncostatin receptor 2.0 1.9 1.0 8.2E-08
    AJ010045 Neuroepithelial cell transforming gene 1 1.8 1.4 0.8 1.2E-03
    AW123650 Gap junction membrane channel protein beta 6 1.8 1.5 0.9 4.5E-05
    X84215 Gap junction membrane channel protein beta 1 −1.5 −1.4 1.1 4.3E-04
    AF105222 Leukemia-associated gene-like −1.6 −1.6 1.0 2.2E-05
Transcription regulation
    *U19118 Activating transcription factor 3 (ATF3) 2.4 2.6 1.1 5.4E-08
    X61800 CCAAT/enhancer binding protein (C/EBP), delta 2.1 2.1 1.0 1.7E-05
    M61007 CCAAT/enhancer binding protein (C/EBP), beta 3.0 3.2 1.1 4.9E-03
    AW045443 Myocyte enhancer factor 2A 1.5 1.6 1.1 7.6E-04
    AI848050 Kruppel-like factor 9 1.4 1.4 1.0 2.2E-03
    M28845 Early growth response 1 1.6 1.3 1.0 7.7E-05
    X63866 Cellular nucleic acid binding protein 1.4 1.3 1.0 2.3E-03
    *U20344 Kruppel-like factor 4 (gut) (GKLF) 1.6 1.5 0.9 9.1E-03
    U60453 Enhancer of zeste homolog 1 (Drosophila) 1.4 1.3 0.9 7.7E-05
    *AI843895 Ethanol-induced 6 (Srebpl) 1.4 1.4 1.0 9.2E-09
    AF038848 Transcriptional regulator, S1N3B (yeast) 1.5 1.4 1.0 4.6E-06
    *A67083 CHOP/GADD153 3.6 3.5 1.0 4.6E-05
    U79748 MAD homolog 4 (Drosophila) 1.5 1.3 0.9 1.2E-02
    AF022992 Period homolog (Drosophila) 3.8 2.3 −1.7 2.3E-06
    Y18505 Mus musculus mRNA for XAP-5 protein 1.5 1.5 1.0 9.0E-05
    U183148 NFIL3/E4BP4 1.8 1.7 1.0 4.8E-06
    AB023485 TATA box binding protein, Taf2s 1.6 1.5 0.9 2.2E-04
    AI842969 TAF9 RNA polymerase II 1.5 1.7 1.1 1.4E-03
    AI553024 Zinc finger gene PLZF 2.9 2.0 0.7 1.6E-08
    U57524 I kappa B alpha gene 1.8 1.6 0.9 5.1E-04
    AW047554 Zinc finger protein 96 2.2 1.7 0.8 8.1E-07
    AF017085 General transcription factor II 1 −1.5 −1.5 1.0 8.2E-07
    U31566 NK2 transcription factor related, locus 2 −1.7 −1.5 1.2 2.1E-05
    AF047389 SRY box containing gene 10 −1.4 −1.3 1.1 6.8E-05
    L38607 Forkhead box D1 −1.6 −1.5 1.0 4.9E-04
    AF043220 General transcription factor II 1 −1.5 −1.3 1.2 1.9E-03
    L35032 SRY-box containing gene 18 −1.7 −1.6 1.0 1.2E-02
    AW124932 Pre B-cell leukemia transcription factor 1 −1.9 −1.9 1.0 3.2E-08
    AF015260 MAD homolog 7 (Drosophila) −1.6 −1.5 1.1 8.0E-05
    AW046227 WD40 protein Ciao 1 −1.4 −1.7 0.9 3.2E-04
Transport
    *M22998 Solute carrier family 2 member 1 (Glut 1) 2.0 1.6 0.8 1.9E-07
    AI845514 ATP-binding cassette, subfamily A (ABC1) 2.3 2.2 1.0 1.9E-05
    AI853978 Similar to solute carrier family 21 member 11 −1.6 −1.8 0.9 9.4E-08
Miscellaneous
    AI854154 89% identical to Human ACP33 1.6 1.4 0.9 1.6E-04
    AW125865 Histocompatibility antigen 1.5 1.6 1.0 1.5E-03
    AW046124 Cytochrome b-245, alpha-polypeptide 1.5 1.7 1.1 1.7E-04
    U883327 Cytokine-inducible SH2-containing protein 2 1.5 1.6 1.1 9.5E-03
    AI854020 Cytosolic cysteine dioxygenase 1 1.4 1.4 1.0 4.0E-04
    X15591 Cytotoxic-T-lymphocyte-associated protein 2 alpha 1.6 1.9 1.2 2.1E-03
    AI326963 Fibrinogen/angiopoietin-related protein 1.6 1.6 1.0 9.7E-04
    AI844178 HLA-B-associated transcript 3 2.0 1.3 −1.5 8.7E-03
    V00756 Interferon-related developmental regulator 1 1.4 1.6 1.1 3.0E-03
    C85523 MLV VLeco LTRg 1.7 1.6 0.9 2.8E-04
    AW125442 Protein kinase inhibitor, alpha 1.5 1.6 1.1 1.2E-03
    *AF063095 Sell (suppressor of lin-12) 1 homolog (C. elegans) 1.7 1.6 0.9 2.7E-04
    AI853531 Similar to rat gene 33 polypeptide (GO) 1.4 1.2 0.8 1.4E-04
    AF077527 Syndecan binding protein 1.7 1.4 0.8 5.4E-04
    D29797 Syntaxin 3 1.4 1.5 1.1 7.8E-04
    X52102 Synaptotagmin interacting protein 1.4 1.4 0.9 2.3E-03
    Z70023 Gap junction membrane channel protein beta 6 1.5 1.5 1.0 5.1E-03
    AW212859 Axotrophin 1.4 1.5 1.1 1.7E-02
    AA790056 Cysteine- and histidine-rich protein 1.8 1.9 1.0 1.7E-03
    AA674143 Rattus norvegicus synaptojanin 2 binding protein −1.5 −1.6 0.9 3.9E-06
    AW061161 Asparaginase-like sperum autoantigen −1.7 −1.7 1.0 4.7E-06
    L16992 Branched chain ketoacid dehydrogenase E1, beta −1.4 −1.4 1.1 2.3E-03
    X99641 Chromobox homolog 5 (Drosophila HP1a) −1.4 −1.3 1.1 8.7E-05
    U82758 Claudin 5 −1.7 −1.4 1.2 1.5E-03
    *D16333 Coproporphyrinogen oxidase (Cpo) −1.7 −1.8 0.9 1.1E-07
    AW122453 Cys- and His-rich domain (CHORD)-containing −1.8 −2.1 0.9 3.3E-07
    D88792 Cysteine-rich protein 2 −1.6 −2.0 0.8 4.2E-05
    AI842825 Glycolipid transfer protein −1.6 −1.5 1.1 5.8E-06
    U18773 GPI-anchored membrane protein 1 −1.6 −1.4 1.1 3.4E-05
    AI839882 Homolog to oligo-RNase −1.8 −1.7 1.1 1.3E-06
    AI465543 Homolog to protein ad-004 (protein cgi-137) −1.7 −2.0 0.9 1.9E-04
    AI843232 Succinyl-coa: 3-ketoacid-coenzyme a transferase −1.7 −1.9 0.9 2.6E-05
    AF079528 Immediate early response 5 −1.4 −1.5 1.0 6.0E-04
    AI850297 Junction cell adhesion molecule 2 −2.0 −2.6 0.8 1.1E-05
    D16141 Lethal giant larval homolog −1.5 −1.4 1.1 3.2E-07
    AW124555 Methylmalonyl CoA epimerase (MCEE), mRNA −1.4 −1.5 1.0 4.8E-05
    AF060883 Mucin 14, endothelial −1.4 −1.5 1.0 3.2E-04
    AI850965 NADPH oxidase homolog −1.4 −1.4 1.0 1.5E-05
    AA986258 Phosphorylated adaptor for RNA export −1.4 −1.4 1.0 3.1E-04
    AV319920 Protein kinase WNK1 (WNK1) mRNA −1.7 −2.0 0.9 9.4E-03
    U35374 Purine-nucleoside phosphorylase −1.5 −1.4 1.1 6.0E-04
    AI592541 Ret finger protein 2 −1.4 −1.4 1.0 8.6E-04
    AA716963 Similar to isopentenyl-diphosphate delta −2.7 −2.6 1.0 1.3E-07
    AI854285 Similar to kelch family protein Ndl-L −1.5 −1.6 0.9 2.5E-04
    *U44088 T-cell death associated gene (Tdag) −1.5 −1.4 1.1 2.5E-05
    X70956 Topoisomerase (DNA) I −1.5 −1.5 1.0 1.3E-04
    U67611 Transaldolase 1 −1.6 −1.5 1.1 1.1E-05
    AF061516 Vesicle-associated membrane protein 4 −1.7 −1.9 0.9 1.9E-05
a

Function based on GO annotation (3) or deduced from relevant literature.

b

GenBank accession numbers.

c

Changes (n-fold) in pathogenic versus nonpathogenic viruses.

d

Mock inoculated.

e

Calculated with ANOVA FDR < 5%.

f

*, gene involved in ER stress.

g

LTR, long terminal repeat.