TABLE 4.
Number of mutations in the 5′-untranslated region-P1 coding region (versus Sabin 2) shared by the isolatesa
Isolate name | No. of mutations shared
|
||
---|---|---|---|
P2S/Mog65-2 | P2S/Mog65-3 | P2S/Mog66-4 | |
P2S/Mog65-1 | 2 | 2 | 3 + 1 |
P2S/Mog65-2 | 2 | 1 | |
P2S/Mog65-3 | 1 |
Underlined numbers correspond to mutations A481→G (in the 5′-untranslated region) shared by all four isolates and U2909→C (corresponding to the replacement of Ile143 of VP1 by Thr) shared by the isolates P2S/Mog65-1, P2S/Mog65-2, and P2S/Mog65-3. In isolate P2S/Mog66-4, the same U residue mutated into A, resulting in the Ile143→Asn change. The total numbers of nucleotide substitutions in the 5′-untranslated region-P1 coding region, compared to the Sabin 2 ancestor, are 18, 6, 22, and 46 for the isolates P2S/Mog65-1, P2S/Mog65-2, P2S/Mog65-3, and P2S/Mog66-4, respectively.