Table 3.
Sample | Bmax of [3H]ryanodine binding (% of control) | 45Ca2+ uptake rate (% of control) |
---|---|---|
Control | 100 | 100 |
Junctin knockdown | 63 ± 9* | 89 ± 12 |
Triadin knockdown | 113 ± 54 | 107 ± 16 |
Junctin/triadin knockdown | 77 ± 32 | 92 ± 7 |
The total number of [3H]ryanodine binding sites (Bmax) and 45Ca2+ uptake rates of crude membrane fractions were determined as described in Materials and methods. Data are mean ± S.E. of six experiments.
p < 0.05 compared to control.