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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cell Cycle. 2008 Oct 7;7(19):2949–2955. doi: 10.4161/cc.7.19.6760

Table 2.

Effect of IM on expression of IGF Pathway Genesa

Sample KIT/PDGFRα genotype IGF1R IGF2R IGF1 IGF2
1 wild type 17.3 0.86 69 0.15
2 not available 1.60 0.50 0.66 0.60
3 KIT exon 11 mutant 29.1 0.11 2.18 0.04
4 KIT exon 11 mutant 46.5 0.43 63.9 0.55
a

Values given are ratios of RNA expression levels in post/pre samples. RNA, extracted from flash-frozen biopsy specimens and from resected tumors following up to 8 weeks of IM treatment was subjected to quantitative RT-PCR analysis using TaqMan gene expression assays. RNA levels were first normalized to HPRT.