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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Neurobiol Dis. 2008 Jul 3;32(1):26–36. doi: 10.1016/j.nbd.2008.06.013

Figure 1. Ih is increased 1–2 d after a single episode of status epilepticus (SE).

Figure 1

A, representative traces showing the voltage responses measured at either the soma or distal dendrite from control (black) or 1–2 d after SE (red) CA1 pyramidal neurons. B, Summary graph showing that 1–2 d after SE input resistance measured at the soma was significantly reduced compared to control. Note that in control CA1 pyramidal neurons, input resistance was significantly lower in the distal dendrite compared to the soma. This difference is not present in CA1 pyramidal neurons 1–2 d after SE. **p< 0.01 compared to control; #p < 0.05 compared to soma. C, representative traces showing the voltage response to a hyperpolarizing current injection measured at either the soma or distal dendrite from CA1 pyramidal neurons in control (black) or 1–2 d after SE (red). D, Summary graph showing that 1–2 d after SE voltage sag measured at the soma was significantly increased compared to control. Note that in control CA1 pyramidal neurons, voltage sag was significantly higher in the distal dendrite compared to the soma. This difference is not present in CA1 pyramidal neurons 28–30 d after SE. *p< 0.05 compared to control; #p< 0.05 compared to soma. E, representative traces showing the voltage response to train of αEPSCs injected and recorded at either the soma or distal dendrite of control (black) or 1–2 d after SE (red). F, Summary graph showing that 1–2 d after SE temporal summation measured at the soma was significantly reduced compared to control. Note that in control CA1 pyramidal neurons, temporal summation was significantly lower in the distal dendrite compared to the soma. This difference is not present in CA1 pyramidal neurons 1–2 d after SE. *p< 0.05 compared to control; #p< 0.05 compared to soma. G, Representative somatic and dendritic impedance amplitude profile from a control (black) and 1–2 day post SE neuron (red). The dashed lines indicate the resonance frequency (fR). Note the rightward shift in the SE neuron. H, Summary graph showing that 1–2 d after SE fR measured at the soma was significantly increased compared to control. Note that in control CA1 pyramidal neurons, fR was significantly higher in the distal dendrite compared to the soma. This difference is not present in CA1 pyramidal neurons 28–30 d after SE. *p< 0.05 compared to control; #p< 0.05 compared to soma.