Skip to main content
. Author manuscript; available in PMC: 2009 Jan 14.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May;49(5):2148–2155. doi: 10.1167/iovs.07-1012

Figure 2.

Figure 2

Light-adapted retinal function after TUDCA treatment in rd10 mice at P30. A) ERG waves recorded in response to a series of Ganzfeld flashes in the presence of an adapting background light (30 cd/m2). The vehicle-treated mouse shows a slight decrease in sensitivity with the first recordable response at −0.4 log cd s/m2. At the brightest flashes, the TUDCA-treated mouse had ERG b-wave amplitudes that were twice the size of a vehicle-treated control. B) Average ERG amplitudes (± SEM) for light-adapted a- and b-waves are plotted across intensity. The cone-mediated b-wave in the TUDCA-treated group (n=15) is significantly different compared to the vehicle group (n=10) [F (6, 138) = 6.364, p < 0.001]. The a-wave amplitude is not quite statistically significantly different between the groups [Repeated ANOVA; F(6, 120) = 2.075, p = 0.061]. We conclude that TUDCA is efficacious in preserving cone-mediated electrical responses in the retina.