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. Author manuscript; available in PMC: 2009 Jan 14.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May;49(5):2148–2155. doi: 10.1167/iovs.07-1012

Figure 4.

Figure 4

Cone opsin labeling in WT and rd10 mice after TUDCA treatments at P30. Each micrograph is presented as a pair with the DIC image on the right and the cone opsin labeling on the left. A) Cone opsin immunohistochemistry in a WT retina showing distinct outer segments of cones. B and C) TUDCA-treated rd10 retinas showing long cone outer segments, similar to WT retina (B) and shorter cone outer segments with more punctuate labeling (C). D and E) Cone labeling in vehicle-treated rd10 retinas appeared as sparse punctuate labeling. Note that no outer segments are visible in the DIC images of the vehicle-treated mice. These results suggest that TUDCA treatments preserve cone outer segments.