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(A) Scanning EM of neuroblastoma tumorsphere shows a smooth and uniform surface. (B) Microvilli-like structures shown on the tumorsphere surface by transmission EM in cross-section. (C) Transmission EM shows tight packing of tumor cells in the tumorsphere core. (D) Apoptotic tumorsphere cell shows nuclear blebbing, chromatin fragmentation and mitochondrial swelling.
