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. 2009 Jan 21;4(1):e4235. doi: 10.1371/journal.pone.0004235

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Mahller et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Side population analysis using Hoechst 33342, +/−verapamil, of bulk LA-N-5 cells (LAN5) and LA-N-5 cells grown in doxorubicin (LAN5-dox^R). (B) Analysis of ABCG2 and CD133 expression in LAN5 and LAN5-dox^R cells. (C) Sphere-forming efficiency of sorted SP and non-SP (NSP) cells from LAN5 and LAN5-dox^R cultures. (D) Sorted SP and NSP cells, from cultures of LAN5 and LAN5-dox^R, were plated in serum containing media for 2 weeks and re-evaluated by side population, +/−verapamil. SP-derived cultures show regeneration of SP and NSP cells, while NSP-derived cultures showed only regeneration of NSP cells, not SP cells.