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. 2008 Dec;173(6):1714–1723. doi: 10.2353/ajpath.2008.080622

Figure 6.

Figure 6

Reduced expression of Th17-promoting cytokines in the intestinal lamina propria lymphocytes from KCV-treated mice as well as iNKT-deficient mice. A: RORãt expression in the intestinal LP after treatment with oral KCV. Total RNA was isolated from pooled LPLs prepared from wild-type control B6 mice (WT control), KCV-treated wild-type B6 mice (WT KCV), and control Jα281−/− mice (Jα281−/− control) (n = 2). Wild-type KCV were given oral KCV for 7 days before the analysis. RORγt mRNA was estimated by quantitative RT-PCR and all data were normalized to hprt. Data are representative of two independent experiments. B: Expression of Th17-promoting cytokines in the intestinal LPL. Total RNA was isolated from LPLs of the three groups of mice as described in (A). Expression of TGFβ−1, IL-6, IL-23, and IL-21 mRNA was estimated by quantitative RT-PCR and all data were normalized to hprt. Data are a representative of two independent experiments.