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. 2008 Dec;173(6):1758–1767. doi: 10.2353/ajpath.2008.080363

Figure 5.

Figure 5

Interaction of AR and MCM7 leading to increase or decrease of DNA synthesis. A: Incorporation of bromo-uridine into DNA of LNCaP cells, or PC3 cells transfected with pCMV-AR, or PC3 cells transfected with pCMV-ΔAR. B: Induction of cell proliferation or cell growth arrest by R1881 in LNCaP, PC3+AR, and PC3+ΔAR cells. Cells were treated with indicated amounts of R1881 and pulsed labeled with bromo-uridine for 24 hours. The cells were subsequently stained with FITC-conjugated antibodies against bromo-uridine and propidium iodide. FACS analyses were performed to determine the cell cycle distribution of these cells. Standard deviations are indicated.