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. 2008 Dec;173(6):1911–1918. doi: 10.2353/ajpath.2008.080457

Figure 1.

Figure 1

Prorenin expression is up-regulated in CNV and PRRB inhibits CNV. A: Up-regulation of prorenin mRNA levels in the RPE-choroid complex by inducing CNV (n = 6 to 7). B: (Pro)renin receptor mRNA levels were unchanged following CNV induction (n = 6 to 7). C: Flatmounted choroids from vehicle-, CP-, and PRRB-treated mice. D: The graph shows the CNV volume. PRRB application led to significant suppression of CNV, compared with vehicle or CP treatment. Arrowheads in (C) indicate lectin-stained CNV tissues (n = 33 to 37. **P < 0.01, *P < 0.05). Scale bars = 100 μm.