Figure 5. Regulation of LXR signaling by SULT2b1 during T cell activation.
(A) Real-time PCR analysis of LXRβ and ABCG1 from quiescent WT T cells cultured with simvastatin and 5 mM mevalonic acid. (B) Real-time PCR analysis of SULT2b1, ABCC1, LDLR and ABCG1 mRNA from purified WT T cells stimulated with anti-CD3 in vitro for the indicated times. (C) Real-time PCR analysis of SULT2b1 and ABCG1 mRNA from purified WT T cells stimulated for 12 h with anti-CD3 in vivo. (D) Real-time PCR analysis of LXRβ, LDLR and ABCA1 mRNA from CAR-tg T cells transduced with SULT2b1- containing or control Adenovirus.