Table 1.
Anthropometric and metabolic parameters at baseline and after 20 wk intervention according to PLIN4 and PLIN6 variants
|
PLIN4 11482G→A
|
PLIN6 14995A→T
|
|||||
|---|---|---|---|---|---|---|
| GG (n = 116) | GA+AA (n = 118) | P | AA (n = 134) | AT+TT (n = 100) | P | |
| Baseline | ||||||
| Age (yr) | 10.7 ± 1.3 | 10.6 ± 1.3 | 0.91 | 10.7 ± 1.4 | 10.6 ± 1.2 | 0.83 |
| Weight (kg) | 66.8 ± 14.1 | 69.8 ± 16.5 | 0.18 | 69.1 ± 16.3 | 67.3 ± 14.1 | 0.43 |
| BMI (kg/m2) | 30.1 ± 3.9 | 30.6 ± 5.0 | 0.53 | 30.7 ± 4.7 | 30.0 ± 4.1 | 0.28 |
| BMI Z-score | 2.30 ± 0.3 | 2.32 ± 0.3 | 0.88 | 2.32 ± 0.3 | 2.29 ± 0.3 | 0.46 |
| Waist circumference (cm) | 95.7 ± 9.5 | 97.1 ± 11.7 | 0.39 | 97.1 ± 11.4 | 95.6 ± 9.6 | 0.33 |
| Blood pressure systolic (mm Hg) | 111 ± 13 | 113 ± 16 | 0.42 | 112 ± 14 | 112 ± 15 | 0.99 |
| Blood pressure diastolic (mm Hg) | 70 ± 12 | 70 ± 12 | 0.80 | 70 ± 12 | 71 ± 11 | 0.35 |
| Fasting glycemia (mg/dl) | 85 ± 7 | 86 ± 8 | 0.16 | 85 ± 8 | 86 ± 7 | 0.37 |
| Fasting insulin (μU/ml) | 16.5 ± 9.8 | 18.6 ± 9.8 | 0.03a | 18.3 ± 10.3 | 16.5 ± 9.1 | 0.20 |
| HOMA-IR | 3.5 ± 2.1 | 4.0 ± 2.3 | 0.02a | 3.9 ± 2.2 | 3.6 ± 2.2 | 0.21 |
| TC (mg/dl) | 158.3 ± 31.9 | 159.5 ± 32.0 | 0.75 | 159.4 ± 34.1 | 158.3 ± 28.7 | 0.98 |
| HDL-C (mg/dl) | 43.6 ± 10.1 | 40.0 ± 9.0 | 0.003a | 42.4 ± 9.9 | 40.9 ± 9.4 | 0.27 |
| LDL-C (mg/dl) | 95.6 ± 28.1 | 97.5 ± 29.3 | 0.64 | 96.3 ± 29.9 | 97.0 ± 27.0 | 0.76 |
| TG (mg/dl) | 93.9 ± 42.5 | 110.7 ± 49.1 | 0.003a | 102.9 ± 46.9 | 101.6 ± 46.5 | 0.98 |
| Diet (kcal/d) | 1951 ± 648 | 2001 ± 672 | 0.69 | 1946 ± 671 | 2031 ± 639 | 0.51 |
| After intervention (20 wk) | ||||||
| Weight (kg) | 64.5 ± 14.5 | 67.1 ± 15.7 | 0.19 | 67.2 ± 16.2 | 64.0 ± 13.4 | 0.43 |
| Weight loss (kg) | 2.4 ± 3.7 | 2.7 ± 3.6 | 0.51 | 1.9 ± 3.5 | 3.3 ± 3.7 | 0.00a |
| BMI (kg/m2) | 28.3 ± 4.3 | 28.8 ± 4.8 | 0.51 | 29.1 ± 4.9 | 27.8 ± 3.9 | 0.04a |
| BMI Z-score | 2.10 ± 0.3 | 2.12 ± 0.4 | 0.65 | 2.14 ± 0.4 | 2.06 ± 0.3 | 0.11 |
| BMI loss Z-score | 0.21 ± 0.2 | 0.19 ± 0.1 | 0.43 | 0.18 ± 0.1 | 0.23 ± 0.2 | 0.01a |
| Waist circumference (cm) | 93.1 ± 9.5 | 94.5 ± 10.6 | 0.51 | 95.5 ± 10.5 | 91.4 ± 9.0 | 0.05a |
| Fasting glycemia (mg/dl) | 80 ± 7 | 80 ± 8 | 0.75 | 80 ± 8 | 80 ± 7 | 0.56 |
| Fasting insulin (μU/ml) | 14.1 ± 7.5 | 15.0 ± 8.0 | 0.51 | 15.5 ± 7.8 | 13.2 ± 7.6 | 0.02a |
| HOMA-IR | 2.7 ± 1.4 | 3.0 ± 1.7 | 0.43 | 3.1 ± 1.5 | 2.6 ± 1.6 | 0.01a |
| TC (mg/dl) | 156.9 ± 29.0 | 158.7 ± 33.2 | 0.79 | 156.6 ± 32.6 | 159.3 ± 29.1 | 0.45 |
| HDL-C (mg/dl) | 47.0 ± 10.7 | 43.6 ± 9.6 | 0.02a | 45.6 ± 10.4 | 44.8 ± 10.1 | 0.64 |
| LDL-C (mg/dl) | 90.4 ± 27.1 | 94.6 ± 31.0 | 0.35 | 91.2 ± 30.7 | 94.3 ± 26.9 | 0.31 |
| TG (mg/dl) | 98.7 ± 46.2 | 102.4 ± 52.1 | 0.71 | 100.2 ± 53.9 | 100.9 ± 42.2 | 0.60 |
| Diet (kcal/d) | 1637 ± 543 | 1493 ± 549 | 0.21 | 1618 ± 551 | 1474 ± 540 | 0.25 |
n = 234.
a
P < 0.05, independent t test.