Table 3.
Anthropometric and metabolic parameters (baseline and after intervention) for haplotypes PLIN4 11482G→A/PLIN6 14995A→T
| Haplotype PLIN4/PLIN6 | GA 1.1 (n = 84, 35.9%) | GT 1.2 (n = 32, 13.7%) | AA 2.1 (n = 50, 21.4%) | AT 2.2 (n = 68, 29%) |
|---|---|---|---|---|
| Baseline | ||||
| Age (yr) | 10.7 ± 1.3 | 10.5 ± 1.4 | 10.6 ± 1.5 | 10.7 ± 1.2 |
| Weight (kg) | 68 ± 14.6 | 63.6 ± 12.2 | 70.9 ± 18.7 | 69 ± 14.7 |
| BMI (kg/m2) | 30.5 ± 4.1 | 29.3 ± 3.2 | 31.1 ± 5.7 | 30.3 ± 4.4 |
| BMI Z-score | 2.31 ± 0.3 | 2.28 ± 0.2 | 2.34 ± 0.3 | 2.30 ± 0.3 |
| Waist circumference (cm) | 96.7 ± 9.7 | 93.2 ± 8.3 | 97.8 ± 13.8 | 96.7 ± 10.1 |
| Blood pressure systolic (mm Hg) | 111 ± 13 | 112 ± 13 | 114 ± 16 | 112 ± 16 |
| Blood pressure diastolic (mm Hg) | 70 ± 13.0 | 72 ± 10 | 70 ± 11 | 70 ± 12 |
| Fasting glycemia (μU/dl) | 84 ± 7.4 | 87 ± 6.7 | 87 ± 7.5 | 86 ± 7.6 |
| Fasting insulin (μU/dl) | 17.8 ± 10.5 | 13.3 ± 6.7 | 19.2 ± 10.1 | 18.1 ± 9.7 |
| HOMA-IR | 3.73 ± 2.2 | 2.85 ± 1.5 | 4.15 ± 2.0 | 3.90 ± 2.4 |
| TC (mg/dl) | 158.5 ± 33.4 | 157.9 ± 28 | 160.9 ± 35.7 | 158.5 ± 29.3 |
| HDL-C (mg/dl) | 43.55 ± 10.3 | 43.66 ± 9.8 | 40.40 ± 9.0 | 39.66 ± 9.0 |
| LDL-C (mg/dl) | 94.83 ± 28.9 | 97.75 ± 26.2 | 98.72 ± 31.7 | 96.57 ± 27.5 |
| TG (mg/dl) | 98.45 ± 46.2 | 81.81 ± 28.2 | 110.38 ± 47.6 | 110.96 ± 50.5 |
| Diet (kcal/d) | 1935 ± 587 | 2024 ± 923 | 1965 ± 811 | 2033 ± 539 |
| After intervention (20 wk) | ||||
| Weight (kg) | 66.2 ± 14.7 | 60 ± 13.0 | 68.9 ± 18.5 | 65.8 ± 13.3 |
| Weight loss (kg) | 1.90 ± 3.7 | 3.59 ± 3.6 | 1.98 ± 3.1 | 3.20 ± 3.8 |
| BMI (kg/m2) | 28.9 ± 4.4 | 26.9 ± 3.6 | 29.4 ± 5.6 | 28.3 ± 4.0 |
| BMI Z-score | 2.13 ± 0.3 | 2.00 ± 0.3 | 2.16 ± 0.4 | 2.10 ± 0.4 |
| BMI loss Z-score | 0.18 ± 0.1 | 0.29 ± 0.2 | 0.18 ± 0.1 | 0.20 ± 0.1 |
| Waist circumference (cm) | 94.2 ± 9.0 | 88.8 ± 10.9 | 98.4 ± 12.9 | 92.3 ± 8.4 |
| Fasting glycemia (μU/dl) | 80 ± 7.4 | 81 ± 7.4 | 82 ± 7.9 | 80 ± 7.4 |
| Fasting insulin (μU/dl) | 14.4 ± 7.3 | 12.9 ± 8.1 | 17.2 ± 8.4 | 13.3 ± 7.4 |
| HOMA-IR | 2.80 ± 1.3 | 2.42 ± 1.5 | 3.49 ± 1.8 | 2.64 ± 1.6 |
| TC (mg/dl) | 156.2 ± 29.4 | 158.8 ± 28.5 | 157.5 ± 38 | 159.5 ± 29.6 |
| HDL-C (mg/dl) | 47.21 ± 10.4 | 46.50 ± 11.5 | 42.91 ± 10.0 | 44.05 ± 9.3 |
| LDL-C (mg/dl) | 89.53 ± 27.7 | 92.68 ± 26.0 | 93.98 ± 35.5 | 95.03 ± 27.5 |
| TG (mg/dl) | 98.85 ± 47.0 | 98.25 ± 44.8 | 102.63 ± 64.6 | 102.20 ± 41.2 |
| Diet (kcal/d) | 1664 ± 585 | 1551 ± 406 | 1550 ± 505.5 | 1439 ± 597 |