Table 2.
Serum sex hormones, IGF-I, and IGFBP-3
| Placebo
|
DHEA
|
||||
|---|---|---|---|---|---|
| Baseline | 12 months | Baseline | 12 months | P valuea | |
| Women | |||||
| DHEAS (μmol/liter) | 1.2 (0.7) | 1.1 (0.7) | 1.5 (1.0) | 7.1 (5.0) | <0.001 |
| Total testosterone (nmol/liter)b | 1.0 (0.3) | 0.9 (0.4) | 1.2 (0.8) | 2.2 (1.3) | <0.001 |
| SHBG (nmol/liter) | 182.5 (83.7) | 183.2 (88.4) | 149.1 (67.1) | 121.9 (61.7) | 0.005 |
| FTI (pmol/liter)c | 7.0 (4.0) | 8.0 (4.0) | 9.0 (6.0) | 25.0 (15.0) | <0.001 |
| E2 (pmol/liter) | 116.7 (43.0) | 118.9 (45.9) | 113.8 (30.8) | 183.2 (71.6) | <0.001 |
| E1 (pmol/liter) | 94.7 (43.3) | 94.0 (37.4) | 105.0 (42.9) | 187.2 (99.1) | <0.001 |
| FEI (pmol/liter)c | 2.2 (1.2) | 2.3 (1.0) | 2.3 (1.4) | 5.1 (2.7) | <0.001 |
| IGF-I (nmol/liter) | 14.8 (6.6) | 13.8 (5.2) | 14.0 (5.3) | 17.2 (6.3) | 0.028 |
| IGFBP-3 (nmol/liter) | 114.8 (31.2) | 117.6 (34.3) | 119.7 (36.4) | 118.3 (36.4) | 0.941 |
| Men | |||||
| DHEAS (μmol/liter) | 1.7 (0.7) | 2.9 (0.6) | 1.7 (0.7) | 8.8 (4.9) | <0.001 |
| Total testosterone (nmol/liter) | 13.9 (4.6) | 14.1 (4.7) | 13.6 (3.9) | 12.4 (3.2) | 0.114 |
| SHBG (nmol/liter) | 126.0 (64.3) | 126.7 (66.5) | 107.8 (41.4) | 96.7 (39.3) | 0.037 |
| FTI (pmol/liter) | 156.0 (48.0) | 161.0 (42.0) | 169.0 (52.0) | 172.0 (56.0) | 0.417 |
| E2 (pmol/liter) | 171.4 (45.2) | 175.8 (34.1) | 174.7 (42.6) | 235.3 (83.3) | 0.001 |
| E1(pmol/liter) | 127.2 (58.1) | 128.0 (53.3) | 119.5 (53.6) | 176.8 (102.1) | 0.022 |
| FEI (pmol/liter) | 5.9 (1.6) | 6.0 (1.4) | 6.6 (1.4) | 8.7 (2.9) | 0.001 |
| IGF-I (nmol/liter) | 15.5 (6.5) | 14.1 (5.6) | 15.5 (5.6) | 16.0 (6.1) | 0.207 |
| IGFBP-3 (nmol/liter) | 98.7 (34.0) | 96.2 (36.0) | 104.6 (34.3) | 104.0 (36.0) | 0.413 |
Values are mean (sd).
a
Between-group comparisons of 12-month values; differences between groups at baseline were not significant (P > 0.05).
b
Total testosterone was below the limit of detection (0.59 nmol/liter) in 26 women (11 placebo, 14 DHEA) at baseline and 16 women (11 placebo, five DHEA) at 12 months.
c
Cases with undetectable total testosterone concentrations were assumed to be 0.58 nmol/liter for the calculations of the FTI and FEI.