Table 4.

Associations of DHEA treatment and 12-month serum sex hormone concentrations with changes in BMD^a

	Coefficient (P value)
Model	DHEA	Testosteroneb	E2b
Total hip BMD
DHEA	1.14 (0.019)
T		0.00 (0.991)
E2			2.03 (<0.001)
T + E2		−0.31 (0.056)	2.44 (<0.001)
DHEA + T	1.18 (0.018)	−0.07 (0.666)
DHEA + E2	0.22 (0.686)		1.91 (<0.001)
DHEA + T + E2	0.17 (0.742)	−0.31 (0.059)	2.34 (<0.001)
Femoral shaft BMD
DHEA	1.56 (0.019)
T		0.01 (0.971)
E2			2.15 (0.001)
T + E2		−0.37 (0.099)	2.68 (<0.001)
DHEA + T	1.63 (0.017)	−0.10 (0.634)
DHEA + E2	0.60 (0.432)		1.84 (0.016)
DHEA + T + E2	0.56 (0.460)	−0.36 (0.105)	2.38 (0.004)
Trochanter BMD
DHEA	1.46 (0.027)
T		−0.03 (0.878)
E2			2.31 (0.001)
T + E2		−0.34 (0.120)	2.75 (<0.001)
DHEA + T	1.49 (0.025)	−0.08 (0.688)
DHEA + E2	0.62 (0.386)		2.00 (0.011)
DHEA + T + E2	0.54 (0.452)	−0.33 (0.137)	2.47 (0.004)
Lumbar spine BMD
DHEA	1.09 (0.108)
T		0.12 (0.545)
E2			0.93 (0.145)
T + E2		−0.04 (0.875)	0.99 (0.183)
DHEA + T	1.06 (0.125)	0.08 (0.696)
DHEA + E2	0.82 (0.281)		0.59 (0.401)
DHEA + T + E2	0.81 (0.288)	−0.01 (0.969)	0.61 (0.458)

DHEA, DHEA replacement group; T, serum total testosterone. 

^aAdjusted for baseline BMD. 

^blog₂.