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. 2008 Sep 30;93(12):4909–4916. doi: 10.1210/jc.2008-0605

Figure 1.

Figure 1

Antagonism of GLP-1 by Ex-9 in healthy humans. A, Blood glucose during the hyperglycemic clamps with GLP-1 infusion (0.5 pm/kg · min) alone (filled dark circles) or GLP-1 plus Ex-9 infusion at doses of 300 pm/kg · min (open circles) or 600 pm/kg · min (filled gray circle). In this paradigm, both doses of Ex-9 blocked the insulinotropic effect of GLP-1 comparing plasma insulin (B) and C-peptide (C) response to iv glucose infusion (dark bars) and iv glucose plus GLP-1 infusion (light bars) in three studies. Data presented as mean ± sem.