Table 1.
Time (min) | Saline infusion | Ex-9 infusion |
---|---|---|
Blood glucose (mmol/liter) | ||
Baseline | 4.6 ± 0.1 | 4.6 ± 0.1 |
70–90 | 8.9 ± 0.1 | 9 ± 0.1a |
95–270 | 8.7 ± 0.1 | 8.8 ± 0.1 |
Insulin (pmol/liter) | ||
Baseline | 60.1 ± 13.2 | 58.0 ± 13 |
70–90 | 282.5 ± 42 | 263.8 ± 59 |
95–270 | 1154.8 ± 203 | 835.7 ± 120a |
C peptide (nmol/liter) | ||
Baseline | 0.8 ± 0.2 | 0.8 ± 0.1 |
70–90 | 2.7 ± 0.3 | 2.3 ± 0.3a |
95–270 | 6 ± 0.7 | 4.9 ± 0.7b |
Glucagon (pg/ml) | ||
Baseline | 47.9 ± 3.6 | 53.0 ± 5.4 |
80–90 | 43.8 ± 4.5 | 47.2 ± 4.6 |
AUC glucagon(pg/ml · min) | ||
95–270 | 221 ± 353 | 1657 ± 699a |
Glucose infusion rate (mg/kg · min) | ||
70–90 | 6.4 ± 0.8 | 5.6 ± 0.7 |
95–270 | 10.6 ± 1.0 | 8.1 ± 0.9a |
d-xylose (mmol/liter) | ||
95–120 | 0.34 ± 0.03 | 0.38 ± 0.02 |
95–270 | 0.61 ± 0.05 | 0.69 ± 0.03 |
AUC 13C-glucose enrichment (atom %) | ||
95–120 | 19.2 ± 2.2 | 20.1 ± 2.6 |
AUC GLP-1 (pmol/liter · min)c | ||
95–270 | 531 ± 137 | 1208 ± 246b |
AUC GIP (nmol/liter · min)c | ||
95–270 | 19.3 ± 2 | 19.7 ± 2 |
The paired t-test or Wilcoxon rank test was used for comparison of individual values during the respective periods.
P < 0.05 vs. saline infusion.
P < 0.01 vs. saline infusion.
GIP and GLP-1 values were measured for nine and eight subjects, respectively.