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. 2003 Dec;23(23):8637–8650. doi: 10.1128/MCB.23.23.8637-8650.2003

FIG. 7.

FIG. 7.

N2IC permits B-cell commitment but inhibits B2 B-cell development at the pre-B-cell stage. (A) Frequency of B220+ cells expressed as a percentage of the GFP+ population in N2IClo, N2IChi, and control bone marrow (BM) analyzed 3- to 6-weeks PT. (B) Decline in frequency of B220+ cells within the GFP+ population of N2IChi bone marrow as T cells expand. (C) CD19 expression on GFP+ B220+ gated cells (left) and BP-1 and c-kit expression on CD19+ gated cells (right) from N2IClo bone marrow. (D) Representative expression profile for CD43 and IgM on B220+ GFP+ gated cells from N2IClo and control bone marrow. (E) Compiled data showing the frequencies of Hardy fraction subsets expressed as percentages of GFP+ B220+ derived from N2IClo and control bone marrow analyzed 3- to 6-weeks PT and of N2IChi bone marrow analyzed ≤ 3-weeks PT. The data were compiled from analyses of N2IClo mice (n = 12) from three independent experiments and N2IChi mice (n = 4) from two independent experiments. Ctrl, control.