TABLE 1.
Activation by AR coactivatorsalegend
| Coactivator | Activation (fold)
|
||
|---|---|---|---|
| Wild-type AR | ARK630Q | ARK630T | |
| ARA55 | 5.2 | 7.2 | 13.5 |
| ARA70 | 6.1 | 7.5 | 9.6 |
| SRC-1 | 3.3 | 7.7 | 10.9 |
| TIP60 | 4.2 | 6.6 | 10.2 |
| Ubc-9 | 20.1 | 29.8 | 72.0 |
legend
aThe MMTV-Luc reporter was transfected into DU145 cells with the expression vector for hAR and the AR coactivators as detailed in Materials and Methods, and cells were treated with DHT (10−7 M) for 24 h. Data are means ± standard errors of the means compared with the control empty expression vector.