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. Author manuscript; available in PMC: 2009 Jan 14.
Published in final edited form as: J Am Chem Soc. 2007 Feb 22;129(11):3408–3419. doi: 10.1021/ja066362+

Table 2.

Reduction of Weinreb Amides

Entry Amide Product Time (min) Yield (%)
1 graphic file with name nihms-61943-t0033.jpg graphic file with name nihms-61943-t0034.jpg 15 85
2 graphic file with name nihms-61943-t0035.jpg graphic file with name nihms-61943-t0036.jpg 5 94
3 graphic file with name nihms-61943-t0037.jpg graphic file with name nihms-61943-t0038.jpg 5 89
4 graphic file with name nihms-61943-t0039.jpg graphic file with name nihms-61943-t0040.jpg 5 93
5 graphic file with name nihms-61943-t0041.jpg graphic file with name nihms-61943-t0042.jpg 10 89
6 graphic file with name nihms-61943-t0043.jpg graphic file with name nihms-61943-t0044.jpg 10 82
7 graphic file with name nihms-61943-t0045.jpg graphic file with name nihms-61943-t0046.jpg 20 91a
8 graphic file with name nihms-61943-t0047.jpg graphic file with name nihms-61943-t0048.jpg 10 86
9 graphic file with name nihms-61943-t0049.jpg graphic file with name nihms-61943-t0050.jpg 20 93
10 graphic file with name nihms-61943-t0051.jpg graphic file with name nihms-61943-t0052.jpg 20 87b
a

Two equivalents of 1 were required.

b

The corresponding alcohol was also obtained (12%).