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. Author manuscript; available in PMC: 2009 Jan 14.
Published in final edited form as: J Am Chem Soc. 2007 Feb 22;129(11):3408–3419. doi: 10.1021/ja066362+

Table 6.

Reduction of Amides Containing Chiral Auxiliaries

Entry Amide Product Time (min) Yield (%)
1 graphic file with name nihms-61943-t0083.jpg graphic file with name nihms-61943-t0084.jpg 15 92
2 graphic file with name nihms-61943-t0085.jpg graphic file with name nihms-61943-t0086.jpg 90 51
3 graphic file with name nihms-61943-t0087.jpg graphic file with name nihms-61943-t0088.jpg 30 46
4 graphic file with name nihms-61943-t0089.jpg graphic file with name nihms-61943-t0090.jpg 90 57
5 graphic file with name nihms-61943-t0091.jpg a 10 0
6 graphic file with name nihms-61943-t0092.jpg graphic file with name nihms-61943-t0093.jpg 15 90
7 graphic file with name nihms-61943-t0094.jpg N.R. 45 0
8 graphic file with name nihms-61943-t0095.jpg N.R. 45 0
a

Complete loss of starting material without observation of aldehyde.