Table 3. Association of risk factors with an indeterminate QuantiFERON-TB® Gold In-tube result.
Parameter | n | Univariate analysis | Multivariate analysis | ||
OR (95% CI) | p | OR (95% CI) | p | ||
Male sex | 104 | 2.96 (0.96–9.18) | 0.06 | 3.25 (1.00–10.49) | 0.05 |
Age>33 years | 71 | 2.75 (1.09–6.91) | 0.03 | 2.51 (0.56–11.28) | 0.23 |
BMI <18.5 | 98 | 0.81 (0.33–1.98) | 0.64 | 0.68 (0.26–1.77) | 0.43 |
CD4 cell count <300 cells/µl | 62 | 2.83 (1.14–7.00) | 0.02 | 3.41 (1.25–9.29) | 0.02 |
Lymphocyte count <1640 cells/µl | 83 | 1.42 (0.58–3.45) | 0.44 | 1.21 (0.43–2.92) | 0.81 |
3+ AFB by sputum smear microscopy | 70 | 1.86 (0.61–5.67) | 0.27 | 1.57 (0.57–4.27) | 0.38 |
A total of 23 out of 161 patients (14%) had a QFT-IT indeterminate result. No differences were found in OR when comparing QFT-IT positive and negative patients. OR: Odds Ratio. CI: Confidence interval. BMI: Body Mass Index. Age of 33 years and lymphocyte count of 1640 cells/µl represents medians for all patients. 3+ AFB by sputum smear microscopy: More than 10 acid fast bacilli (AFB) per field.