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. 2009 Jan 19;4(1):e4220. doi: 10.1371/journal.pone.0004220

Table 3. Association of risk factors with an indeterminate QuantiFERON-TB® Gold In-tube result.

Parameter n Univariate analysis Multivariate analysis
OR (95% CI) p OR (95% CI) p
Male sex 104 2.96 (0.96–9.18) 0.06 3.25 (1.00–10.49) 0.05
Age>33 years 71 2.75 (1.09–6.91) 0.03 2.51 (0.56–11.28) 0.23
BMI <18.5 98 0.81 (0.33–1.98) 0.64 0.68 (0.26–1.77) 0.43
CD4 cell count <300 cells/µl 62 2.83 (1.14–7.00) 0.02 3.41 (1.25–9.29) 0.02
Lymphocyte count <1640 cells/µl 83 1.42 (0.58–3.45) 0.44 1.21 (0.43–2.92) 0.81
3+ AFB by sputum smear microscopy 70 1.86 (0.61–5.67) 0.27 1.57 (0.57–4.27) 0.38

A total of 23 out of 161 patients (14%) had a QFT-IT indeterminate result. No differences were found in OR when comparing QFT-IT positive and negative patients. OR: Odds Ratio. CI: Confidence interval. BMI: Body Mass Index. Age of 33 years and lymphocyte count of 1640 cells/µl represents medians for all patients. 3+ AFB by sputum smear microscopy: More than 10 acid fast bacilli (AFB) per field.