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. 2009 Jan 19;206(1):79–87. doi: 10.1084/jem.20081667

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© 2009 Ichinohe et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Differential requirement for NLRP3, ASC, and caspase-1 for immunoglobulin isotype responses to influenza virus. WT, NLRP3-, ASC-, caspase-1–, IL-1R–, and MyD88-deficient mice were infected intranasally with a sublethal dose (10 PFU) of A/PR8 virus. Serum and nasal swab were collected at 2 wk p.i. A/PR8-specific nasal IgA levels were measured by ELISA (A). A/PR8-specific serum antibody titers were determined by serial dilution of serum total IgG (B), IgG1 (C), IgG2c (D), IgG3 (E), and IgM (F). These figures are representative of three similar experiments. *, P < 0.05; **, P < 0.01; and ***, P < 0.001 versus WT mice.