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. 2009 Jan 19;206(1):233–248. doi: 10.1084/jem.20080752

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© 2009 Gräbner et al.

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Figure 6. — Media SMCs sandwiched between lesions and ATLOs are activated and express the lymphorganogenic chemokines CXCL13 and CCL21. (a) CXCL13 and CCL21 of ATLO-burdened aorta segment (top). Media SMCs and cells with DC morphology stain positive for CXCL13 in B cell follicle (top left, open triangles) and for CCL21 in T cell area (top right, filled arrows), whereas SMCs of aorta segments without adjacent ATLO (thoracic aorta with plaque) do not (bottom). Medium-sized ATLO blood vessels stain positive for CCL21 (top right, filled arrows), whereas small blood vessels (top right, open arrows) in B cell follicles are CCL21⁻. L, lymph vessel; P, plaque. (b) Colocalization of SMA and CXCL13 and SMA and CCL21 with VCAM-1 in abdominal aorta segments adjacent to ATLO. Bars, 100 μm.