Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Jan 19;206(1):113–123. doi: 10.1084/jem.20081244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 Schellings et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — SPARC expression is induced after MI. (A) SPARC protein is increased after MI in mice. Representative Western blots of SPARC in remote and infarcted LV from WT mice at 3, 7, and 14 d after MI (n = 4 per time point; *, P < 0.05). (B–D) SPARC immunofluorescent staining (green) is absent in sham-operated hearts (B) and remote LV (R-LV), gradually increases in the infarct border LV (IB-LV; C), and is strongly up-regulated in the infarcted LV (I-LV) 7 d after MI (C and D). (E–J) SPARC expression (E and H) colocalizes with α–smooth muscle cell (SMC) actin–positive myofibroblasts (F and G) and CD45 immunoreactive leukocytes (I and J) in the infarcted LV of WT infarcted hearts 7 d after MI. The insets in H–J show detailed SPARC and CD45 immunoreactive leukocytes. Error bars represent the mean ± SEM. Bars: (B–D, H, and J) 100 μm; (E–G) 50 μm.