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. 2009 Jan 19;206(1):113–123. doi: 10.1084/jem.20081244

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© 2009 Schellings et al.

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Figure 4. — SPARC overexpression increases collagen deposition and quality after MI. (A and B) Representative Western blots showing a 2.8-fold increase of SPARC in plasma (A) and a 2.6-fold increase of SPARC in the infarct area (B) of AdSPARC-treated WT mice in comparison with AdR5-treated WT mice at 14 d after MI (n = 4; *, P < 0.05). (C–F) Sirius red staining and polarization microscopy revealed increased collagen deposition in AdSPARC-treated (D) in comparison with AdR5-treated WT infarcts (C) and more well aligned and tightly packed (orange-red) collagen fibers in AdSPARC-treated (F) in comparison with AdR5-treated WT infarcts (E). Error bars represent the mean ± SEM. Bars: (C and D) 2 mm; (E and F) 200 μm.