Table II.
Transcript levels of SPARC-related factor messenger RNAs (mRNAs)
| Sham
|
3-d MI
|
|||||||
|---|---|---|---|---|---|---|---|---|
| WT M (n = 7) |
WT F (n = 7) |
KO M (n = 7) |
KO F (n = 7) |
WT M (n = 6) |
WT F (n = 8) |
KO M (n = 5) |
KO F (n = 10) |
|
| SMOC1 | 11 ± 1.1 | 12 ± 1.5 | 13 ± 4.3 | 11 ± 1.4 | 35 ± 6.8a | 34 ± 5.3a | 26 ± 6.4a | 27 ± 5.4a |
| SMOC2 | 5.0 ± 0.9 | 10 ± 0.5b | 7.3 ± 0.6 | 9.3 ± 0.3b | 3.4 ± 0.5 | 3.0 ± 0.5a | 4.2 ± 0.7a | 4.8 ± 0.6ac |
| Hevin | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.1c | 0.8 ± 0.1 | 0.7 ± 0.1a | 0.6 ± 0.1 | 0.7 ± 0.1 |
| SPARC | 3.4 ± 1.5 | 1.8 ± 0.1 | ND | ND | 14 ± 1.6a | 16 ± 1.8a | ND | ND |
M, male; F, female; ND, not detectable. Numbers are in arbitrary units.
a
P < 0.05 in MI group versus respective sham.
b
P < 0.05 between males and females of the same genotype.
c
P < 0.05 between WT and SPARC-null mice of the same gender.