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. 2009 Jan 19;206(1):43–49. doi: 10.1084/jem.20081438

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© 2009 Veldhoen et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Substitution of RPMI with tryptophan improves Th17 differentiation. (A) Scatter plot showing the percentage of IL-17 producers in CD4 T cells from wild-type B6 (filled triangles) or AhR-deficient mice (open circles) cultured under Th17-polarizing conditions in IMDM (left) or RPMI (right) with or without addition of 11 mg/liter of l-tryptophan. P values are shown in the graph. Data from four independent experiments are shown. (B) IL-17/IL-22 expression in CD4 T cells cultured under Th17 conditions in either IMDM (left) or RPMI (right) in the absence or presence of AhR agonist FICZ after 4 d of culture or (C) in the presence of neutralizing antibodies to IFN-γ and IL-4. Dot plots are representative of three independent experiments.