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. 2009 Jan 19;206(1):43–49. doi: 10.1084/jem.20081438

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© 2009 Veldhoen et al.

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Figure 5. — IL-2 blockade together with AhR activation restored Th17 differentiation. (A) Intracellular IL-17/IL-22 in Th17 cells developing in IMDM (left) or RPMI medium (right) without (top) or with addition of neutralizing antibodies to IL-2 (bottom). Dot plots are representative of three independent experiments. (B) Expression of phospho-Stat5 in CD4 T cells cultured under Th17 conditions in IMDM (top) or RPMI (bottom) in the absence of exogenous AhR agonist (left), with FICZ (middle), or in the presence of neutralizing antibodies to IL-2 (right). Histograms (representative of three independent experiments) of gated CD4 T cells showing phospho-Stat5 expression at 48 h after onset of culture are shown. (C) IL-17/IL-22 expression in Th17 cells cultured in IMDM (left) or RPMI (right) in the presence of neutralizing antibodies to IL-2 and FICZ. Dot plots are representative of three independent experiments.