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Loss of Rb is associated with increased proliferation in the CNS. E12.5 mouse embryos were fixed, cryosectioned, and stained for proliferation (BrdU). Loss of Rb enhanced cell proliferation in certain compartments of the CNS (A–D). In ST (I–L) and MO (M–P), but not CSM (E–H), and midbrain (MB; Q–T) of the Rb−/− and TKO CNS cell proliferation was increased. (Scale bar: 500 μm, A–H; 50 μm, E–T).
