Fig. 6.

Long-term (3 months) treatment of T2320 induces the formation of nodules in VP of WT mice. After short-term (3 weeks) exposure to T2320, there were no significant morphologic changes in the VP of WT mice (A, vehicle; B, T2320). Upon long-term (3 months) treatment with T2320, WT mice developed fibrous nodules in VP ducts (D). Over the same period, vehicle-treated WT mice did not develop any nodules (C). VP in long-term T2320-treated WT mice (red arrows in H) showed a decrease of LXRα level compared with vehicle-treated WT mice (G) and short-term-treated WT mice (E, vehicle; F, T2320). LXRα-positive cells are indicated by black arrows in E–G. (Scale bars: 50 μm.)