Fig. 8.

Increased expression of the proliferation marker, Ki67, in VP of LXR mutant mice at ages 11 months (A and B) and 17 months (C-H). Columnar epithelial ducts (A and C) and cuboidal epithelial ducts (B and D) were evaluated separately for Ki67-positive epithelial cells. The results are presented as Ki67-positive cells per 1,000 epithelial cells (mean ± SD). Five mice were used for each genotype. **, P < 0.01; ***, P < 0.001, vs. WT control, Student's t test. Representative Ki67 staining in 17-month-old LXR mutant mouse VP compared with WT mice (E, WT; F, LXRα^−/−; G, LXR β^−/−; H, LXRαβ^−/−). (Scale bars: E–H, 50 μm.) Arrows indicate Ki67-positive cell nuclei.