FIG. 6.

(A) Western blots showing reduced fibrillarin protein expression in mouse embryonic fibroblasts derived from Fibrillarin^+/− mice. The left panel shows the endogenous fibrillarin protein detected with a specific antibody. The middle panel shows the fibrillarin-βgeo fusion protein detected with an anti-β-galactosidase antibody. The right panel shows total proteins detected by Coomassie blue staining. (B) Localization of fibrillarin-βgeo fusion protein and of endogenous fibrillarin in mouse embryonic fibroblasts derived from +/+ and +/− mice with antibodies specific to β-galactosidase and fibrillarin, respectively.