TABLE 3.
Rearrangement rate of the Line 78 palindrome in cell line 7#7-7-6
| Day of culture | No. of doublingsa | Intact/totalb (x/y) | Fraction intact | Ratec | 95% CId |
|---|---|---|---|---|---|
| 21 | 28 | 19/25 | 0.76 | 8.6 | 3.6-19.0 |
| 39 | 52 | 31/46 | 0.67 | 7.0 | 4.1-11.8 |
| 64 | 85 | 24/43 | 0.56 | 6.4 | 4.0-10.0 |
| 80 | 106 | 24/45 | 0.53 | 5.8 | 3.5-8.7 |
| 126 | 168 | 22/49 | 0.45 | 5.0 | 3.3-7.0 |
a
Calculated from a doubling time of 18 h.
b
Clones with an intact Line 78 transgene/total number of clones analyzed.
c
Rate of rearrangement per population doubling (value listed × 10−3 gives rate), calculated by the MLE (see Materials and Methods).
d
The 95% CI (values listed × 10−3 gives interval), calculated by the MLE (see Materials and Methods for details).