Table 1.
Results of the cognitive and clinical assessments at screening
| Cognitive domains/Tests | Participant A | Participant B | ||
|---|---|---|---|---|
| Raw score | AEMSS* score | Raw score | AEMSS score | |
| Global cognitive functioning | ||||
| DRS-2 | ||||
| Total score (max. 144) | 108 | 0 | 119 | 1 |
| Raw scores | Z scores | Raw scores | Z scores | |
| MMSE | 19 | < −3.0 | 25 | −1.79 |
| Total score (max. 30) | ||||
| Episodic memory | ||||
| CVLT (French version) | ||||
| List A – Sum of trials 1 to 5 | 17 | −2.50 | 26 | −1.6 |
| List B – Immediate recall | 0 | < −3.0 | 2 | −2.0 |
| List A – Short term free recall | 0 | −2.5 | 0 | −2.5 |
| List A – Short term cued recall | 3 | −3.0 | 2 | < −3.0 |
| List A – Delayed free recall | 0 | −3.0 | 0 | −3.0 |
| List A – Delayed cued recall | 0 | < −3.0 | 2 | −3.0 |
| Recognition – True positives | 8 | < −3.0 | 15 | 0.5 |
| Recognition – False positives | 17 | −3.0 | 19 | < −3.0 |
| Semantic memory/Language | ||||
| BNT (30-item version) | 21 | −2.0 | 15 | −2.0 |
| Verbal fluency | ||||
| Phonemic | 17 | −2.52 | 27 | −1.59 |
| Semantic | 9 | −2.02 | 8 | −2.02 |
| Executive functions | ||||
| Tower of London | ||||
| Total move score | 145 | < −2.67 | 27 | 0.8 |
| Trail Making Test | ||||
| Visual scanning | 73 | −3.0 | 36 | −1.0 |
| Number sequencing | 150 | −3.0 | 27 | 1.33 |
| Letter sequencing | 150 | −3.0 | 21 | 1.33 |
| Number-Letter Switching | 240 | −3.0 | 91 | 0.67 |
| Motor speed | 118 | −3.0 | 20 | 1.0 |
| Clock Drawing Test | ||||
| Copy (max. 10) | 5 | < −3.0 | 9 | 0 |
| Free drawing (max. 10) | 6 | −2.63 | 10 | 0.95 |
| Activities of daily living | ||||
| DAD (%) | 73% | 86% | ||
| Neuropsychiatric symptoms | 18 | 3 | ||
| NPI (max. 144) | ||||
*
Note: Age and Education Corrected Scaled Score.
Abbreviations: