TABLE 3.
Characteristics of the single-step mutant P18 and wild-type strain ISP794
| Strain | MIC (μg/ml) of:
|
Mutations
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Premafloxacin | Ciprofloxacin | Novobiocin | Nalidixic acid | Ethidium bromide | grlA | parE | gyrA | gyrB | norA promoter | |
| ISP794 | 0.004-0.008 | 0.125-0.25 | 0.064-0.128 | 64-128 | 2.0-4.0 | |||||
| P18 | 0.016-0.032 | 1.0 | 0.064 | 128 | 4.0 | None | −13 (G→A) | None | None | None |